The ending was a bit out there for me as in 5. But them even including Wesker back in the game was a big plus for me.
As for the story, the main idea of it is what's intriguing to me. I can't think of any plot holes right now, but I am sure there are a bunch. 5's story wasn't as strong as previous editions, but I do find it a plus over 4. They just took it out of the world of RE for me and throw something new in it all together. Ick. Their idea to have it in Spain should have stayed with the ultimate creation of Devil May Cry as they felt their first try was too fair away from the resident evil series and I feel the second try at it was no better. However I do like the Devil May Cry series though I really need to finish one of them these days
And I agree that from 4 and up the horror factor has been slipping away. 5 tried to bring it back a bit, but it just wasn't the same. Before it used to be about suspense and seeing what was around the corner and now it's just hordes of enemies just attacking you leaving you in an area for way to long, when before it was like I have the get the hell out of here!
The scene in 2 where you run by a window and something quickly passes by and then you get the short cutscene that introduces the licker was brilliant IMO. Ever since that scene and because of it the Licker has been one of my favorite monsters. When they brought them back in 5 I did like the part where you had to walk by the glassed wall rooms with all the lickers waiting for them to bust free and then try to get into the elevator as quickly as possible. However when you get to that large underground dirt room with the catwalk and they all start charging you, well that was a bit much.
People should be warned that this whole thread is just full of spoilers